The four most used setting I use in Paint Tool Sai.
Color refers to a Pen like tool, I use it for line art and coloring.
Everything else there is standard, and the "Sketch," brush is a modified "Color," tool with a lower density, edge hardness and set to 32 on the Hard/Soft scale, I don't use it much anymore because I have the B Pencil Brush from
Edit: The Paint tool is seen using 4 brushtex's; the first two are custom made, and the other two are presets.
Also, the smudge is just the Blend with a higher Density, Persistence and lower Dilution, I just don't use it much to mention it in the picture.